Two recently published studies have demonstrated that the canine anti-emetic Cerenia® (maropitant - Pfizer) which was launched last year also relieves car sickness in dogs.

In a pilot study, 17 dogs were given either Cerenia or placebo one hour before being taken on a car journey. After a washout period of 10-14 days, each dog was crossed over to the other treatment and once again taken on a journey to assess travel sickness. The results showed that likelihood of vomiting was reduced by 70% when the dogs were given Cerenia compared to placebo - but due to the small number of dogs enrolled the results did not reach statistical significance.

The same research group also carried out a large, multicentre, blinded and placebo controlled study of Cerenia in preventing vomiting in 213 dogs known to be prone to travel sickness. They were given a single oral dose of Cerenia or placebo one hour before a car journey. The results showed that Cerenia was associated with a reduction in vomiting of 79% compared to placebo (p<0.0001).>

The dosage of Cerenia used in both studies was 8mg/kg dose for the prevention of motion sickness-higher than the 2mg/kg dose that is routinely used to treat general emesis, administered at least one hour before the journey. According to the researchers' report in the Veterinary Record, the need for a higher dose is linked to the specific neural (central) pathway of emetic stimulation that is involved in motion sickness. Cerenia acts primarily at NK1 receptors in the emetic centre and thus has the ability to block vomiting due to vestibular stimuli.

According to Pfizer, a single oral dose lasts for at least 12 hours, so pets can be dosed the night before an early start. For motion sickness prevention, Cerenia is licensed for up to 2 days' consecutive use, so owners can use it for a return journey the next day if need be.

Pfizer also says that market research suggests almost one in five dogs suffers from travel sickness, which is not only inconvenient but does also stop some owners from travelling with their pet. In the past, owners have had to rely on OTC (over the counter) remedies or medicines developed for use in humans to prevent travel sickness. Many of these are ineffective or have unwanted effects such as sedation or extrapyramidial effects in dogs. Cerenia is the first anti-emetic to be developed specifically for use in dogs and was launched in April 2007- higher dose tablets aimed specifically for the prevention of travel sickness are expected to be made available early this year.

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